The Midtown area is a general mixed-use community area of neighborhoods containing successive waves of development that have transformed the area multiple times since it was first platted. The neighborhoods are dominated by the thoroughfare of Woodward Avenue, which runs north and south through the heart of Midtown.

Woodward Avenue, running north and south through the center of the neighborhood, is primarily inhabited by commercial businesses, public-oriented/cultural institutions, and religious buildings. The heart of the cultural center (the Detroit Public Library and the Detroit Institute of Arts) is located directly on Woodward in the northern part of Midtown.